Products DermiGen: Tension Bioreactor with Air/Media Interface

Watch a video of the DermiGen bioreactor.

The DermiGen bioreactors impart static and oscillatory stimulation to a "skin like" sample in a unique air-to-nutrient media interface. Applications include investigating cell function and stimulating the growth and development of engineered tissues.  The device can also be used as a "test bed" for pharmaceutical and regenerative therapies. The DermiGen can apply either stress or strain using operator defined wave forms.

D70-1 DermiGen

The D70-1 system is configured as a single sample bioreactor system that is able to support a wide range of of cell and tissue growth experiments via user defined stimulating protocols.  The chamber's unique design provides an air/media interface to facilitate cell co-culture and the development of skin like products. The chamber provides media perfusion/flow along the underside of the construct while preventing it from migrating onto the topside.  Mechanical clamp grips with soft linings provide secure positioning of the sample. This chamber can accommodate a single sample with a maximum length of 45-70mm, 20mm width  and 0.1 to 2mm thickness. The instrument may be customized to specific research applications.

D70-4 DermiGen

The D70-4 DermiGenhas been designed as a multi-stimulator bioreactor system. The GrowthWorks Software/Controller operates four (4) independent D70-1 Stimulators to provide increased sample capabilities. As with the D70-1, these instruments may be customized for specific research applications.

GrowthWorks® Software & Control:

The GrowthWorks Software and Control platform includes advanced capabilities, such as multiple waveform control, data acquisition and multi-motor operation. The intuitive software runs on a Windows® laptop computer and features a simple user interface. User defined stimulation profiles are controlled by the software and are readily monitored using graphical displays. Integrated data acquisition routines capture and record data at user prescribed intervals. The GrowthWorks Software is configurable for running four stimulators while simultaneously monitoring up to 16 transducers, allowing the researcher maximum flexibility.

The GrowthWorks Control Hardware features an embedded Intel CPU, integrated data acquisition and integrated motor drives. Communications between the laptop and control hardware is transmitted over a standard network cable. Primary advantages of the BISS Laptop/Controller approach are reduced physical size and easy upgradability. As future Windows versions or higher performance Laptops become available, either can be replaced without any software or controller changes. This ensures the GrowthWorks control system will be an integral part of your research for many years to come.

GrowthApps Stiffness Measurement & Adaptive Control:

The GrowthApps modules provide added capability to GrowthWorks. The addition of the Stiffness Measurement & Adaptive Control Application enables the system to make real-time measurements of the sample stiffness during culture. Described in U.S. Patent 7,410,792 B2 Instrumented bioreactor with material property measurement capability and process-based adjustment for conditioning tissue engineered medical products., the Application measures the mechanical response of the tissue construct as it is being stimulated and conditioned. The stiffness measurements can be used as guidelines for bench marking progress during culturing or for modifying the stimulation profile. Based upon the measured response, the bioreactor system is then capable of altering the stimulation profile. This technology enables researchers to automatically culture the skin from initial seeding to an implantation-ready state with minimal operator intervention.

 

SKIN
Key: S=Standard, A=Available, - = not available
CHAMBERS D70-1 D70-4
Individual growth chamber S S
4 parallel growth chambers - A
Max construct size: 70mm long x 20mm wide x 2mm thick S S


STIMULATION    
Static or oscillatory tension A A


CONTROLS    
Controller software, computer, and monitor S S
Power supplies and cabling S S
Mean flow control S S
Dynamic flow control S S


TISSUE MONITORING    
Non-contact flow sensors A A
Catheter pressure transducers A A


ACCESSORIES    
Media reservoir S S
Incubator A A


BENEFITS    
All-autoclavable components S S
Excellent sample access S S
Medium change without opening chamber via luer fittings S S
Increased sterility with fast and clean sample change and access S S
Lightweight design for easy handling S S
Easily cleaned surface finishes S S
Compact design for fit in standard incubators S S
100% satisfaction guaranteed warranty S S

 

Download the 2015_DermiGen

ABOUT BISS TGT

Did you know that BISS TGT has a wide range of products for Tissue Engineering and Regenerative Medicine (TERM) Applications? Our innovative material testing technology is the most comprehensive commercial solution for the TERM market! We are proud to present BISS TGT TERM.

SERVICE & SUPPORT

OUR CUSTOMERS

  • Children's Mercy Hospital and Clinics
  • Cook Biotech
  • Drexel University
  • FDA Center for Devices and Radiological Health
  • Gel-Del Technologies
See Full List

LATEST NEWS

  • The Challenges of Tissue Characterization
    05.27.2014

    The Challenges of Tissue Characterization TERM research is poised to change the way we know health care. This cutting-edge technology demands new tools and solutions that are able to keep up with the development in personalized medicine. Instron® is delivering those solutions.

    More Info
  • BISS featured in THE HINDU
    07.23.2015

    Bangalore Integrated System Solutions (BISS), a leading test equipment manufacturer, prides in not just ‘making in India’ but also in engaging Indian minds and hands for the same. BISS is a Bengaluru-based developer, manufacturer and exporter of digitally-controlled precision test systems for material and component characterisation in industry, R&D and academia.

    More Info
  • As Featured in Quality Magazine
    10.15.2014

    All parties recognize the importance of developing test standards and providing the est possible medical devices, but determining the best methods is a challenge.

    More Info
  • Instron TERM - Video
    10.01.2014

    See the magic of Instron TERM characterize tissue and culture cells.

    More Info
  • Biomedical Advances
    11.19.2014

    Instron TERM's quarterly newsletter is focused on research and product development challenges in the tissue engineering and regenerative medicine field. Topics include new customer applications, new Instron products, and technology innovation updates.

    More Info
  • Instron TERM sponsors ISACB Webinar Series
    01.08.2015

    Register today for the Winter 2015 Webinar on February 5, 2015. "Stem Cell Therapy for Cardiovascular Disease: From Cell to Heart" Robert Deans, PhD & Keith March, MD, PhD

    More Info
Bangalore Integrated System Solutions (P) ltd.
+91 80 28360184 | tgt@biss.in
Copyright © 2015 - 2017 Bangalore Integrated System Solutions (P) ltd. . All Rights Reserved. BISS aquired Tissue Growth Technologies (TGT)